Insights

Latest analyses and perspectives on AI in chemistry, pharma, and biotech.

Response Surface Methodology, End to End

A response surface methodology tutorial with real CovaDOE output: 18-run CCD, quadratic fit R2 0.9988, optimum with CIs, design space and residual.

August 10, 2026

Use Case8 min read

High Concentration Antibody Viscosity: Predict It Early

High concentration antibody viscosity decides whether your mAb can be a subcutaneous injection. Predict it from sequence, with real CovaBio tool output.

August 8, 2026

Guide8 min read

HPLC Column Selection and Method Scouting

HPLC column selection method development: phase chemistry, selectivity vs efficiency, scouting gradients, with real ChromaOpt tool output and its limits.

August 7, 2026

Explainer7 min read

ICH M7 Classification: Class 1 to 5, by Example

ICH M7 classification explained class by class, with the dual (Q)SAR assessment and five real impurities scored live by CovaTox, including NDMA and.

August 6, 2026

Explainer8 min read

pLDDT Explained: When to Trust a Predicted Structure

pLDDT interpretation for practitioners: what the bands mean, why a global mean hides the region you care about, and real CovaFold numbers showing what MSA.

August 6, 2026

Guide8 min read

ADC Design: DAR, Linker and Payload Liabilities

ADC design from sequence: DAR distribution, conjugation site counts, linker stability and the hydrophobicity/aggregation trade-off, with real covabio_adc.

August 4, 2026

Guide9 min read

UV Dissolution Testing: f2, Sink Conditions, Limits

UV dissolution testing end to end: calibration, ICH Q2(R2) validation, f1/f2 similarity, sink conditions, and where UV loses to HPLC. Real CovaUV output.

August 2, 2026

Use Case8 min read

QbD Process Development: Screen, RSM, ML in One Run

A QbD process development workflow end to end: DoE screen, response surface, ML model on one 29-run Pd coupling, with every number a real CovaDOE and.

July 31, 2026

Explainer8 min read

Docking Score Interpretation: What -10 kcal/mol Means

Docking score interpretation, honestly: what a -10 kcal/mol Vina score does and does not tell you, using a real CovaDock run on KRAS G12C.

July 31, 2026

Use Case8 min read

LNP Formulation Optimization for mRNA

LNP formulation optimization for mRNA with real CovaLNP tool output: MC3 baseline 86.3% EE, 94.9 nm, PDI 0.150, and an NSGA-II Pareto front reaching 88.0%.

July 30, 2026

Use Case7 min read

Ionizable Lipid Screening Straight From SMILES

Ionizable lipid screening without burning stock: rank custom lipids from SMILES, pick the most informative next run, and see the real size trade-off.

July 27, 2026

Explainer8 min read

Split-Plot Designs for Hard-to-Change Factors

A split plot design DoE worked through with real CovaDOE output: whole-plot vs sub-plot structure, why full randomisation fails in a reactor, and the.

July 24, 2026

Explainer8 min read

Definitive Screening Design: A Real 13-Run Example

What a definitive screening design is, shown with a real 13-run DSD for 6 factors generated by CovaDOE, plus power numbers and the interaction aliasing.

July 22, 2026

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