Insights

Latest analyses and perspectives on AI in chemistry, pharma, and biotech.

ADC Design: DAR, Linker and Payload Liabilities

ADC design from sequence: DAR distribution, conjugation site counts, linker stability and the hydrophobicity/aggregation trade-off, with real covabio_adc.

July 15, 2026

Explainer8 min read

AI Retrosynthesis: Routes You Can Actually Run

AI retrosynthesis planning explained with a real ChemReason run on celecoxib: what the model returned, which disconnections a chemist can run, and what it.

July 15, 2026

Comparison8 min read

AlphaFold3 Alternatives in 2026: An Honest Comparison

AlphaFold3 alternatives compared: OpenDDE, ESMFold2, Protenix, OpenFold3, Boltz-1 and Chai-1 on a published antibody-antigen benchmark, plus our own.

July 15, 2026

Use Case8 min read

Antibody Developability Prediction From Sequence

Antibody developability prediction from sequence alone: real CovaBio output on trastuzumab re-finds its documented CDR and Fc liabilities before wet-lab.

July 15, 2026

Use Case7 min read

Antisolvent Crystallization Design: Pick the Route First

Antisolvent crystallization design in practice: how to choose antisolvent vs cooling, set the volume fraction, and predict yield before you touch.

July 15, 2026

Explainer8 min read

Applicability Domain in QSAR: When a Model Says I Don't Know

What the applicability domain in QSAR is, how Tanimoto, feature range and leverage methods define it, and how CovaTox downgrades out-of-domain predictions.

July 15, 2026

Guide8 min read

Augment a Screening DoE into a Response Surface

How to augment a DoE design to an RSM: turn a 13-run screening design into a 21-run CCD with 8 new runs instead of starting over with 17.

July 15, 2026

Explainer8 min read

Binding Site Druggability Prediction, Honestly Read

Binding site druggability prediction explained: how geometric pocket detection works, what the score means, and a real CovaFold run on KRAS G12C that.

July 15, 2026

Comparison8 min read

Central Composite vs Box-Behnken: Which Design, When

Central composite vs Box-Behnken on the same 3 factors: real CovaDOE run counts, axial points, power and the corners each design does not visit.

July 15, 2026

Guide8 min read

PDE vs TTC in Cleaning Validation: The Genotoxic Case

PDE vs TTC cleaning validation: when a health-based PDE applies, when ICH M7 forces the 1.5 ug/day TTC, and how to check the residue is even cleanable.

July 15, 2026

Comparison8 min read

Co-Folding vs Docking: Which Question Are You Asking?

Cofolding vs docking: what ipTM and a docking score each actually measure, with real CovaFold ipTM 0.99 and CovaDock -10.35 kcal/mol output on KRAS G12C.

July 15, 2026

Comparison8 min read

Cooling vs Antisolvent: Choosing the Isolation Route

Cooling vs antisolvent crystallization: how supersaturation is generated, when cooling simply cannot work, and a worked CovaSolv example - 0.0% vs 99.96%.

July 15, 2026

Explainer8 min read

Which CPP Actually Drives Your Variability

Critical process parameter sensitivity: how Morris, Sobol and SHAP differ, and a worked CovaOPT example ranking temperature against catalyst, base and.

July 15, 2026

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