Insights

Latest analyses and perspectives on AI in chemistry, pharma, and biotech.

Design Space, NOR and PAR: ICH Q8 Explained

ICH Q8 design space, NOR and PAR defined precisely, with real CovaDOE and CovaOPT tool output showing what a tighter spec costs you in operating window.

July 15, 2026

Use Case8 min read

Immunogenicity Prediction for Antibodies: MHC-II Screening

Immunogenicity prediction for antibodies: how MHC-II epitope screening works, real CovaBio output on trastuzumab VH/VL, and what in-silico ADA risk cannot.

July 15, 2026

Use Case7 min read

Ionizable Lipid Screening Straight From SMILES

Ionizable lipid screening without burning stock: rank custom lipids from SMILES, pick the most informative next run, and see the real size trade-off.

July 15, 2026

Use Case8 min read

LNP Formulation Optimization for mRNA

LNP formulation optimization for mRNA with real CovaLNP tool output: MC3 baseline 86.3% EE, 94.9 nm, PDI 0.150, and an NSGA-II Pareto front reaching 88.0%.

July 15, 2026

Guide8 min read

Mass Balance in Forced Degradation, and Why It Fails

Mass balance in forced degradation rarely closes. The four real causes - non-chromophoric and volatile degradants, adsorption, response factors - and how.

July 15, 2026

Explainer8 min read

Mixture Designs for Formulation DoE

Mixture design formulation DoE explained: why components summing to 1 break factorial designs, what L-pseudocomponents do, and real CovaDOE simplex run.

July 15, 2026

Use Case8 min read

Nitrosamine Risk Assessment: An ICH M7 Workflow

A practical nitrosamine risk assessment workflow for NDSRIs: ICH M7 dual assessment, real CovaTox classifications, and where the QSAR goes out of domain.

July 15, 2026

Explainer7 min read

OOT vs OOS in Stability Data: Catching Drift Early

Out of trend stability data explained: how OOT differs from OOS, when regression, CUSUM and Shewhart methods fire, and a worked CovaStab example.

July 15, 2026

Explainer8 min read

PBT Assessment for Pharmaceuticals: Very Toxic Is Not PBT

PBT assessment for pharmaceuticals: how P, B and T differ from GHS aquatic hazard, with real CovaTox ecotox output for three drug molecules.

July 15, 2026

Guide8 min read

pH-Solubility Profiles and Salt Selection

How to build a pH solubility profile for salt selection, with real CovaSolv numbers on ibuprofen, and where Henderson-Hasselbalch stops being true.

July 15, 2026

Explainer8 min read

pLDDT Explained: When to Trust a Predicted Structure

pLDDT interpretation for practitioners: what the bands mean, why a global mean hides the region you care about, and real CovaFold numbers showing what MSA.

July 15, 2026

Explainer8 min read

Cpk vs Ppk: In Control Is Not the Same as Capable

Process capability for pharma: what Cpk and Ppk actually measure, why a stable process can still miss target, and a worked CovaOPT example with real SPC.

July 15, 2026

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