From absorbance to percent released: volume correction for withdrawn samples and the USP <711> stage logic, worked through one run.
August 11, 2026
Insights
Insights
Articles for analytical, QC and CMC teams: spectra, impurities, stability, ICH M7 and HPLC, each with a worked example.
All articles
Guide8 min read
Dissolution Evaluation From UV Data, Step by Step
Guide8 min read
Response Surface Methodology, End to End
A response surface methodology tutorial with a worked example: 18-run CCD, quadratic fit R2 0.9988, optimum with CIs, design space and residual.
August 10, 2026
Use case8 min read
High Concentration Antibody Viscosity: Predict It Early
High concentration antibody viscosity decides whether your mAb can be a subcutaneous injection. Predict it from sequence before formulation work begins.
August 8, 2026
Guide15 min read
HPLC Column Selection and Method Scouting
HPLC column selection chart and decision tree: match C18, phenyl-hexyl, PFP, HILIC or mixed-mode to logD and pKa. Scout fewer columns, start here.
August 7, 2026
Explainer7 min read
ICH M7 Classification: Class 1 to 5, by Example
ICH M7 classification explained class by class, with the dual (Q)SAR assessment and five real impurities scored, including NDMA.
August 6, 2026
Explainer8 min read
pLDDT Explained: When to Trust a Predicted Structure
pLDDT interpretation for practitioners: what the bands mean, why a global mean hides the region you care about, and real numbers on MSA depth.
August 6, 2026
Guide8 min read
ADC Design: DAR, Linker and Payload Liabilities
ADC design from sequence: DAR distribution, conjugation site counts, linker stability and the hydrophobicity/aggregation trade-off, with real data.
August 4, 2026
Guide9 min read
UV Dissolution Testing: f2, Sink Conditions, Limits
UV dissolution testing end to end: calibration, ICH Q2(R2) validation, f1/f2 similarity, sink conditions, and where UV loses to HPLC, with a worked example.
August 2, 2026
Use case8 min read
QbD Process Development: Screen, RSM, Regression Model in One Run
A QbD process development workflow end to end: DoE screen, response surface, regression on one 29-run Pd coupling, with every number really calculated.
July 31, 2026
Explainer8 min read
Docking Score Interpretation: What −10 kcal/mol Means
Docking score interpretation, honestly: what a −10 kcal/mol docking score does and does not tell you, using a real docking run on KRAS G12C.
July 31, 2026
Use case8 min read
LNP Formulation Optimization for mRNA
LNP formulation optimization for mRNA with real results: MC3 baseline 86.3% EE, 94.9 nm, PDI 0.150, and a Pareto front reaching 88.0%.
July 30, 2026
Use case7 min read
Ionizable Lipid Screening Straight From SMILES
Ionizable lipid screening without burning stock: rank custom lipids from SMILES, pick the most informative next run, and see the real size trade-off.
July 27, 2026
Next step
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