Insights

Latest analyses and perspectives on AI in chemistry, pharma, and biotech.

AI Retrosynthesis: Routes You Can Actually Run

AI retrosynthesis planning explained with a real ChemReason run on celecoxib: what the model returned, which disconnections a chemist can run, and what it.

June 30, 2026

Comparison8 min read

Cooling vs Antisolvent: Choosing the Isolation Route

Cooling vs antisolvent crystallization: how supersaturation is generated, when cooling simply cannot work, and a worked CovaSolv example - 0.0% vs 99.96%.

June 28, 2026

Guide8 min read

PDE vs TTC in Cleaning Validation: The Genotoxic Case

PDE vs TTC cleaning validation: when a health-based PDE applies, when ICH M7 forces the 1.5 ug/day TTC, and how to check the residue is even cleanable.

June 25, 2026

Explainer7 min read

Significant Change Under ICH Q1A: What Triggers It

Significant change ICH Q1A explained: the exact assay, degradant, dissolution and physical triggers, and what intermediate testing you owe once it fires.

June 25, 2026

Explainer8 min read

Design Space, NOR and PAR: ICH Q8 Explained

ICH Q8 design space, NOR and PAR defined precisely, with real CovaDOE and CovaOPT tool output showing what a tighter spec costs you in operating window.

June 24, 2026

Use Case8 min read

Nitrosamine Risk Assessment: An ICH M7 Workflow

A practical nitrosamine risk assessment workflow for NDSRIs: ICH M7 dual assessment, real CovaTox classifications, and where the QSAR goes out of domain.

June 24, 2026

Guide8 min read

Extractables and Leachables: A Screening Workflow

A structure-first extractables leachables screening workflow: match peaks to known additives, set the AET, then hand structures to toxicological triage.

June 23, 2026

Guide8 min read

Forced Degradation Study Design (ICH Q1A R2)

Forced degradation study design under ICH Q1A(R2): stressor selection, target degradation levels, mass balance and stability-indicating methods, with real.

June 19, 2026

Guide8 min read

pH-Solubility Profiles and Salt Selection

How to build a pH solubility profile for salt selection, with real CovaSolv numbers on ibuprofen, and where Henderson-Hasselbalch stops being true.

June 19, 2026

Explainer8 min read

Applicability Domain in QSAR: When a Model Says I Don't Know

What the applicability domain in QSAR is, how Tanimoto, feature range and leverage methods define it, and how CovaTox downgrades out-of-domain predictions.

June 14, 2026

Use Case7 min read

Green Solvent Substitution Without Losing Solubility

Green solvent replacement in pharma: rank ICH Q3C Class 3 alternatives to DCM and chloroform by predicted solubility before you book lab time.

June 13, 2026

Guide8 min read

Solvent Selection Under ICH Q3C: A Data Question

Solvent selection under ICH Q3C explained: what Class 1, 2 and 3 mean, the ppm limits, and how predicted solubility narrows the candidate list before lab.

June 13, 2026

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