Choosing the worst-case product for cleaning validation: hardest to remove, tightest limit, and a MACO example with four products.
September 18, 2026
Insights
Insights
Articles for analytical, QC and CMC teams: spectra, impurities, stability, ICH M7 and HPLC, each with a worked example.
All articles
Guide8 min read
Worst-Case Selection for Shared Facilities: Solubility Meets Hazard
Guide7 min read
Metal Binding in Peptides From Apo and Holo Masses
Metal binding from native MS: the mass shift rule for Zn, Cu, Ni and Ca, a worked example and what gas-phase data cannot say.
September 15, 2026
Guide8 min read
From PDF and Image to Clean Structure Data
Getting structures out of PDFs, scans and names into a usable file: the four extraction routes and the standardisation steps that follow.
September 11, 2026
Explainer8 min read
Generative Design That Comes With an Assessment
Why a list of generated molecules is worthless without an assessment, and what a usable run produces: constraints up front, scored output, routes.
September 9, 2026
Guide7 min read
Prioritising Ionisable Lipids With Models
How predicted LNP performance becomes a defensible shortlist: which differences are real and how to break a tie at the top of the list.
September 4, 2026
Guide9 min read
Changing an HPLC Method Without Revalidation: USP <621>
Which HPLC changes USP <621> allows without revalidation: L/dp, flow, injection volume and gradient scaling, with a worked column switch.
September 2, 2026
Guide8 min read
qNMR Purity Without a Certified Reference Standard
qNMR gives purity without a reference standard of your own compound. What you need instead, and the uncertainty budget that makes it a result.
August 31, 2026
Guide8 min read
Making NMR and Chromatography Raw Data Usable
Vendor formats, open standards and the metadata that decides whether archived NMR and HPLC data can be reused, converted or safely discarded.
August 26, 2026
Guide8 min read
ADMET Profiling a Series Without a Cheminformatics Team
How a small team gets a usable ADMET profile for a series: which endpoints to ask for, how to read predictions with intervals and domain flags.
August 24, 2026
Guide8 min read
Fine-Tuning LNP Models on Your Own Formulation Data
Why a public LNP model underperforms on your process, what a usable in-house dataset looks like, and how to split, calibrate and check a fine-tuned model.
August 20, 2026
Guide9 min read
PPQ Readiness: What Your Batch Data Already Tells You
Before process performance qualification: what three batches can show, capability with confidence bounds, tolerance intervals and readiness checks.
August 18, 2026
Explainer8 min read
Method Transfer and Comparability: TOST Explained
Why a t-test is the wrong tool for method transfer and how TOST works, with two worked examples that reach opposite verdicts.
August 13, 2026
Next step
Your question, evaluated for your lab.
30 minutes on Microsoft Teams with the CovaSyn team. If it is not a fit, we will say so.