Insights

Latest analyses and perspectives on AI in chemistry, pharma, and biotech.

Mass Balance in Forced Degradation, and Why It Fails

Mass balance in forced degradation rarely closes. The four real causes - non-chromophoric and volatile degradants, adsorption, response factors - and how.

July 17, 2026

Comparison8 min read

Co-Folding vs Docking: Which Question Are You Asking?

Cofolding vs docking: what ipTM and a docking score each actually measure, with real CovaFold ipTM 0.99 and CovaDock -10.35 kcal/mol output on KRAS G12C.

July 14, 2026

Use Case8 min read

Antibody Developability Prediction From Sequence

Antibody developability prediction from sequence alone: real CovaBio output on trastuzumab re-finds its documented CDR and Fc liabilities before wet-lab.

July 14, 2026

Guide8 min read

Augment a Screening DoE into a Response Surface

How to augment a DoE design to an RSM: turn a 13-run screening design into a 21-run CCD with 8 new runs instead of starting over with 17.

July 11, 2026

Use Case8 min read

Generative Molecule Design That Survives ADMET

Generative molecule design is easy; ADMET filtering is the hard part. A real CovaChem GA analog run through CovaTox and docking, with in-domain flags.

July 8, 2026

Benchmark8 min read

Solubility Prediction Model Accuracy: How to Read It

Solubility prediction model accuracy explained: scaffold vs random splits, RMSE 0.689 on 4,193 held-out rows, and why apparent is not intrinsic solubility.

July 6, 2026

Guide8 min read

Unknown Impurity Identification by LC-MS/MS

Unknown impurity identification by LC-MS: formula from accurate mass, RDBE, isotope pattern and MS/MS fragment logic, with real CovaMS tool output and its.

July 6, 2026

Explainer8 min read

Mixture Designs for Formulation DoE

Mixture design formulation DoE explained: why components summing to 1 break factorial designs, what L-pseudocomponents do, and real CovaDOE simplex run.

July 5, 2026

Comparison8 min read

AlphaFold3 Alternatives in 2026: An Honest Comparison

AlphaFold3 alternatives compared: OpenDDE, ESMFold2, Protenix, OpenFold3, Boltz-1 and Chai-1 on a published antibody-antigen benchmark, plus our own.

July 5, 2026

Explainer8 min read

Which CPP Actually Drives Your Variability

Critical process parameter sensitivity: how Morris, Sobol and SHAP differ, and a worked CovaOPT example ranking temperature against catalyst, base and.

July 4, 2026

Guide7 min read

DoE Power Analysis Before You Run the Experiment

DoE power analysis in plain terms: why a 13-run screening design catches a 1 sigma effect 82% of the time but a 0.5 sigma effect only 31%, and how factor.

July 3, 2026

Use Case7 min read

Antisolvent Crystallization Design: Pick the Route First

Antisolvent crystallization design in practice: how to choose antisolvent vs cooling, set the volume fraction, and predict yield before you touch.

June 30, 2026

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