Insights

Latest analyses and perspectives on AI in chemistry, pharma, and biotech.

Definitive Screening Design: A Real 13-Run Example

What a definitive screening design is, shown with a real 13-run DSD for 6 factors generated by CovaDOE, plus power numbers and the interaction aliasing.

July 15, 2026

Explainer8 min read

Docking Score Interpretation: What -10 kcal/mol Means

Docking score interpretation, honestly: what a -10 kcal/mol Vina score does and does not tell you, using a real CovaDock run on KRAS G12C.

July 15, 2026

Guide7 min read

DoE Power Analysis Before You Run the Experiment

DoE power analysis in plain terms: why a 13-run screening design catches a 1 sigma effect 82% of the time but a 0.5 sigma effect only 31%, and how factor.

July 15, 2026

Explainer7 min read

DoE Residual Diagnostics: Shapiro-Wilk and Cook's D

DoE residual diagnostics explained: what Shapiro-Wilk, Cook's distance and leverage actually tell you about an RSM fit, with real CovaDOE tool output.

July 15, 2026

Guide8 min read

Extractables and Leachables: A Screening Workflow

A structure-first extractables leachables screening workflow: match peaks to known additives, set the AET, then hand structures to toxicological triage.

July 15, 2026

Guide8 min read

Forced Degradation Study Design (ICH Q1A R2)

Forced degradation study design under ICH Q1A(R2): stressor selection, target degradation levels, mass balance and stability-indicating methods, with real.

July 15, 2026

Use Case8 min read

Generative Molecule Design That Survives ADMET

Generative molecule design is easy; ADMET filtering is the hard part. A real CovaChem GA analog run through CovaTox and docking, with in-domain flags.

July 15, 2026

Use Case7 min read

Green Solvent Substitution Without Losing Solubility

Green solvent replacement in pharma: rank ICH Q3C Class 3 alternatives to DCM and chloroform by predicted solubility before you book lab time.

July 15, 2026

Use Case8 min read

High Concentration Antibody Viscosity: Predict It Early

High concentration antibody viscosity decides whether your mAb can be a subcutaneous injection. Predict it from sequence, with real CovaBio tool output.

July 15, 2026

Guide8 min read

HPLC Column Selection and Method Scouting

HPLC column selection method development: phase chemistry, selectivity vs efficiency, scouting gradients, with real ChromaOpt tool output and its limits.

July 15, 2026

Explainer7 min read

ICH M7 Classification: Class 1 to 5, by Example

ICH M7 classification explained class by class, with the dual (Q)SAR assessment and five real impurities scored live by CovaTox, including NDMA and.

July 15, 2026

Guide8 min read

ICH Q1E Shelf Life Calculation from Accelerated Data

ICH Q1E shelf life calculation from accelerated stability data: the method, a worked example with real Arrhenius output, and when extrapolation is not OK.

July 15, 2026

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