A split plot design DoE with real results: whole-plot vs sub-plot structure, why full randomisation fails in a reactor, and how to analyse it correctly.
July 24, 2026
Insights
Insights
Articles for analytical, QC and CMC teams: spectra, impurities, stability, ICH M7 and HPLC, each with a worked example.
All articles
Explainer8 min read
Split-Plot Designs for Hard-to-Change Factors
Explainer8 min read
Definitive Screening Design: A Real 13-Run Example
What a definitive screening design is, shown with a real 13-run DSD for 6 factors, plus power numbers and the interaction aliasing.
July 22, 2026
Guide8 min read
Mass Balance in Forced Degradation: Why It Does Not Close
Why mass balance in forced degradation rarely closes: non-chromophoric and volatile degradants, adsorption and response factors, plus how to close the gap.
July 17, 2026
Comparison8 min read
Co-Folding vs Docking: Which Question Are You Asking?
Cofolding vs docking: what ipTM and a docking score each actually measure, with real ipTM 0.99 and −10.35 kcal/mol on KRAS G12C.
July 14, 2026
Use case8 min read
Antibody Developability Prediction From Sequence
Antibody developability prediction from sequence alone: an assessment of trastuzumab re-finds its documented CDR and Fc liabilities before wet-lab.
July 14, 2026
Guide8 min read
Augment a Screening DoE into a Response Surface
How to augment a DoE design to an RSM: turn a 13-run screening design into a 21-run CCD with 8 new runs instead of starting over with 17.
July 11, 2026
Use case8 min read
Generative Molecule Design That Survives ADMET
Generative molecule design is easy; ADMET filtering is the hard part. A real designed analogue run through tox screening and docking, with in-domain flags.
July 8, 2026
Guide8 min read
Unknown Impurity Identification by LC-MS/MS
Unknown impurity identification by LC-MS: formula from accurate mass, RDBE, isotope pattern and MS/MS fragment logic, with a worked example.
July 6, 2026
Explainer8 min read
Mixture Designs for Formulation DoE
Mixture design formulation DoE explained: why components summing to 1 break factorial designs, what L-pseudocomponents do, and worked simplex designs.
July 5, 2026
Explainer8 min read
Which CPP Actually Drives Your Variability
Critical process parameter sensitivity: how Morris, Sobol and SHAP differ, and a worked example ranking temperature against the rest.
July 4, 2026
Guide7 min read
DoE Power Analysis Before You Run the Experiment
DoE power analysis in plain terms: why a 13-run screening design catches a 1 sigma effect 82% of the time but a 0.5 sigma effect only 31%, and how factor.
July 3, 2026
Use case7 min read
Antisolvent Crystallization Design: Pick the Route First
Antisolvent crystallization design in practice: how to choose antisolvent vs cooling, set the volume fraction, and predict yield before you touch.
June 30, 2026
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