Insights

Latest analyses and perspectives on AI in chemistry, pharma, and biotech.

QbD Process Development: Screen, RSM, ML in One Run

A QbD process development workflow end to end: DoE screen, response surface, ML model on one 29-run Pd coupling, with every number a real CovaDOE and.

July 15, 2026

Guide8 min read

Response Surface Methodology, End to End

A response surface methodology tutorial with real CovaDOE output: 18-run CCD, quadratic fit R2 0.9988, optimum with CIs, design space and residual.

July 15, 2026

Explainer8 min read

Retention Time Prediction in HPLC Method Development

What retention time prediction in HPLC is actually good for, what it is not, and a worked impurity panel with real chromaopt_predict_rt outputs.

July 15, 2026

Comparison8 min read

Screening Designs Compared: Fractional, PB and DSD

Screening design comparison for DoE: fractional factorial vs Plackett-Burman vs definitive screening, with real run counts, resolution and power from.

July 15, 2026

Explainer7 min read

Significant Change Under ICH Q1A: What Triggers It

Significant change ICH Q1A explained: the exact assay, degradant, dissolution and physical triggers, and what intermediate testing you owe once it fires.

July 15, 2026

Benchmark8 min read

Solubility Prediction Model Accuracy: How to Read It

Solubility prediction model accuracy explained: scaffold vs random splits, RMSE 0.689 on 4,193 held-out rows, and why apparent is not intrinsic solubility.

July 15, 2026

Guide8 min read

Solvent Selection Under ICH Q3C: A Data Question

Solvent selection under ICH Q3C explained: what Class 1, 2 and 3 mean, the ppm limits, and how predicted solubility narrows the candidate list before lab.

July 15, 2026

Explainer8 min read

Split-Plot Designs for Hard-to-Change Factors

A split plot design DoE worked through with real CovaDOE output: whole-plot vs sub-plot structure, why full randomisation fails in a reactor, and the.

July 15, 2026

Explainer8 min read

Tool Calling vs Fine-Tuning for Scientific AI

Tool calling vs fine tuning in science: why a purpose-built model plus an LLM caller beats a fine-tuned LLM on determinism, applicability domain and audit.

July 15, 2026

Guide8 min read

Unknown Impurity Identification by LC-MS/MS

Unknown impurity identification by LC-MS: formula from accurate mass, RDBE, isotope pattern and MS/MS fragment logic, with real CovaMS tool output and its.

July 15, 2026

Guide9 min read

UV Dissolution Testing: f2, Sink Conditions, Limits

UV dissolution testing end to end: calibration, ICH Q2(R2) validation, f1/f2 similarity, sink conditions, and where UV loses to HPLC. Real CovaUV output.

July 15, 2026

Use Case9 min read

Shelf-life prediction with Arrhenius: from weeks of data to a shelf-life estimate in minutes

From a few weeks of accelerated stability data to a shelf-life estimate in minutes — on an amoxicillin example. Why the limiting parameter is not assay. And why the tool itself tells you when not to rely on extrapolation alone.

May 24, 2026

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