From the lab
A first risk picture in minutes
A new active ingredient is on the table. Before toxicology starts, the team needs a first risk picture.
How CovaSyn solved it
Two CovaTox queries give the ICH M7 class and all structural alerts within minutes. Where the tool is uncertain it says so; the decision stays with your experts.
Limit according to the tool: A C-F bond is a poor alkylating agent. This is exactly where the expert decides, not the tool.
Tools: CovaTox, CovaChem
The values
| ICH M7 | Class 3, alkyl halide alert, statistics negative |
|---|---|
| Evidence behind the alert | Odds ratio 1.64 in the Ames dataset |
| Structural alerts | 6 alerts, 3 of them hERG motifs, none with high evidence |
| Lipinski | No violation |