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From the lab

An HPLC starting method from the structure

A new compound has no HPLC method yet. Starting from scratch, the first runs cost days.

CAMIZESTRANT · C24H28F4N6An HPLC starting method from the structureCamizestrant, ChromaOptCOLUMNXBridge Phenyl150 x 4.6 mmMOBILE PHASE AH₂Owith 0.1 % TFAMOBILE PHASE BMeCNGRADIENT20 → 95% Bin 12 minutesAccording to the tool, the predicted retention time is only good for the order, not for minutes.Source: ChromaOpt · 2026-09-24REAL COVASYN OUTPUT
Real CovaSyn outputCamizestrant, C24H28F4N6. ChromaOpt, 2026-09-24

How CovaSyn solved it

ChromaOpt proposes a starting method from the structure: column, mobile phase and gradient. Your lab starts with a reasoned first run instead of guessing.

Limit according to the tool: According to the tool, the predicted retention time is only good for the order, not for minutes.

Tools: ChromaOpt

The values

ColumnXBridge Phenyl, 150 x 4.6 mm
Mobile phase AH₂O, with 0.1 % TFA
Mobile phase BMeCN
Gradient20 → 95 % B, in 12 minutes
An HPLC starting method from the structure | CovaSyn