From the lab
Solubility before you go into the lab
How well does the compound dissolve, and how does it behave at physiological pH? The answer decides the next experiments.
How CovaSyn solved it
CovaSyn delivers lipophilicity, polar surface, pKa and solubility together, including a note where the prediction reaches its limits.
Where the result reaches its limits: The molecule lies outside the solubility model's domain. The report states this.
The values
| logP (consensus) | 3.76 |
|---|---|
| TPSA | 60.1 Ų |
| pKa (basic) | 8.6, cationic at pH 7.4 |
| log S in water | -4.7, about 9 µg/mL |
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Results you can rely on
Our beginner's guide for chemistry, pharma and biotech: how to tell an estimate from a calculation, seven questions to ask of every result and six questions to ask every provider. 8 pages.
Next step
Is a similar case waiting in your lab?
Talk it through with us, 30 minutes on Microsoft Teams. Afterwards you know whether we take it on and which data we need.