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An HPLC starting method from the structure

A new compound has no HPLC method yet. Starting from scratch, the first runs cost days.

CAMIZESTRANT · C24H28F4N6An HPLC starting method from the structureCamizestrant, starting methodCOLUMNXBridge Phenyl150 x 4.6 mmMOBILE PHASE AH₂Owith 0.1 % TFAMOBILE PHASE BMeCNGRADIENT20 → 95% Bin 12 minutesThe predicted retention time is only good for the elution order, not for minutes.Source: CovaSyn · 2026-09-24REAL COVASYN OUTPUT
Real evaluation by CovaSynCamizestrant, C24H28F4N6. CovaSyn, 2026-09-24

How CovaSyn solved it

CovaSyn proposes a starting method from the structure: column, mobile phase and gradient. Your lab starts with a reasoned first run instead of guessing.

Where the result reaches its limits: The predicted retention time is only good for the elution order, not for minutes.

The values

ColumnXBridge Phenyl, 150 x 4.6 mm
Mobile phase AH₂O, with 0.1 % TFA
Mobile phase BMeCN
Gradient20 → 95 % B, in 12 minutes

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Results you can rely on

Our beginner's guide for chemistry, pharma and biotech: how to tell an estimate from a calculation, seven questions to ask of every result and six questions to ask every provider. 8 pages.

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An HPLC starting method from the structure | CovaSyn