Development and formulation · Solubility, solvents, crystallization
Our compound will not dissolve, and we have been trying solvents for weeks.
Solvents, mixtures and crystallization route ranked before you use up material.
Who needs this in your company
What we can do
We predict solubility with an interval, including as a pH profile and in mixtures, check miscibility and rank solvents per ICH Q3C. For crystallization we compare cooling and antisolvent routes with the expected yield.
What you get
- Ranked solvents and mixtures
- Counterions and pH profile
- Cooling versus antisolvent comparison with yield
Typical cases
Solve a solubility problem before you run out of material
Our API won't dissolve properly, and we have been trying solvents for weeks.
See solutionCrystallization process design: cooling or antisolvent
Our crystallization yield is too low, and we don't know whether to cool or use an antisolvent.
See solution
Evaluated for you or done yourself
The same calculations, different ways to you. Which one fits, we work out in the intro call.
Sketcher in the browser
Draw a molecule and run the evaluation yourself in the browser.
Free, Pro EUR 250, Max EUR 750 per user and month, net
Learn moreCovaSyn in your AI (MCP)
The same calculations directly in Claude, ChatGPT or your own AI.
Learn moreEvaluation report
You send the data, we deliver the reviewed report.
From EUR 1,490 net, typically 5 working days after complete data
Learn morePilot project
One question on your data, with a success criterion agreed in writing beforehand.
From EUR 1,490 net, fully creditable
Learn more
Limits of the result
- Polymorphism and kinetics are not covered.
- The uncertainty is around one order of magnitude.
More from this area
Synthesis planning and feasibility
We have the target structure, but no route we want to rely on.
Learn moreLNP formulation
Lipid screening and LNP optimisation cost us months in the lab.
Learn moreGreen chemistry and cost
Customers and reports ask for sustainability metrics, and we do not know what a solvent change would gain.
Learn more
Next step
Which case is on your desk right now?
30 minutes on Microsoft Teams with the CovaSyn team. If it is not a fit, we will say so.
